Trifluoromethanesulfonic acid promoted Dakin–West reaction: An efficient and convenient synthesis of β-acetamido ketones
نویسندگان
چکیده
منابع مشابه
One-Pot Synthesis of β-Acetamido Ketones Using Boric Acid at Room Temperature
β-acetamido ketones were synthesized in excellent yields through one-pot condensation reaction of aldehydes, acetophenones, acetyl chloride, and acetonitrile in the presence of boric acid as a solid heterogeneous catalyst at room temperature. It is the first successful report of boric acid that has been used as solid acid catalyst for the preparation of β-acetamido ketones. The remarkable advan...
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چکیده ندارد.
Efficient synthesis of β’-amino-α,β-unsaturated ketones
A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner-Wadsworth-Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
متن کاملOne-Pot Multicomponent Synthesis of β-Acetamido Ketones Using BF3-Et2O as Catalyst
1 Department of Pharmaceutical Sciences, Singhania University, Jhujhunu-333515, Rajasthan, India. 2 National Institute of Pharmaceutical Education & Research, Raebareli229010, Uttar Pradesh, India. A b s t r a c t Starting from different ketones 1a-1f, aldehyde 2a-2g, and acetonitriles 3a-3d we synthesize some bioactive βAcetamido carbonyl compounds 4a-4h. We also attempted to synthesize these ...
متن کاملNano-TiO2: an Eco-friendly and Re-usable Catalyst for the One-pot Synthesis of β-Acetamido Ketones
β -Acetamido ketones are valuable building blocks for the preparation of β -amino ketones or β -amino alcohols such as the antibiotic nikkomycins [1] and neopolyoxines [2]. α-Acetamido ketones are obtained in the Dakin-West reaction [3] and β -acetamido ketones by the Iqbal route. In the latter, an aromatic aldehyde, an enolizable ketone and acetonitrile are condensed in the presence of acetyl ...
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ژورنال
عنوان ژورنال: Journal of Chemical Sciences
سال: 2012
ISSN: 0974-3626,0973-7103
DOI: 10.1007/s12039-011-0183-3